Silencing of Poly(ADP-Ribose) Polymerase-2 Induces Mitochondrial Reactive Species Production and Mitochondrial Fragmentation

PARP2 is a DNA repair protein. The deletion of PARP2 induces mitochondrial biogenesis and mitochondrial activity by increasing NAD(+) levels and inducing SIRT1 activity. We show that the silencing of PARP2 causes mitochondrial fragmentation in myoblasts. We assessed multiple pathways that can lead t...

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Detalles Bibliográficos
Autores principales: Jankó, Laura, Kovács, Tünde, Laczik, Miklós, Sári, Zsanett, Ujlaki, Gyula, Kis, Gréta, Horváth, Ibolya, Antal, Miklós, Vígh, László, Bálint, Bálint L., Uray, Karen, Bai, Péter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227884/
https://www.ncbi.nlm.nih.gov/pubmed/34199944
http://dx.doi.org/10.3390/cells10061387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227884/
https://www.ncbi.nlm.nih.gov/pubmed/34199944
http://dx.doi.org/10.3390/cells10061387

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