Cargando…

Somatic Functional Deletions of Upstream Open Reading Frame-Associated Initiation and Termination Codons in Human Cancer

Upstream open reading frame (uORF)-mediated translational control has emerged as an important regulatory mechanism in human health and disease. However, a systematic search for cancer-associated somatic uORF mutations has not been performed. Here, we analyzed the genetic variability at canonical (uA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jürgens, Lara, Manske, Felix, Hubert, Elvira, Kischka, Tabea, Flötotto, Lea, Klaas, Oliver, Shabardina, Victoria, Schliemann, Christoph, Makalowski, Wojciech, Wethmar, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227997/ https://www.ncbi.nlm.nih.gov/pubmed/34072580 http://dx.doi.org/10.3390/biomedicines9060618

Ejemplares similares

Upstream open reading frames regulate translation of cancer-associated transcripts and encode HLA-presented immunogenic tumor antigens
por: Nelde, Annika, et al.
Publicado: (2022)

Upstream open reading frames: Molecular switches in (patho)physiology
por: Wethmar, Klaus, et al.
Publicado: (2010)

NanoPipe—a web server for nanopore MinION sequencing data analysis
por: Shabardina, Victoria, et al.
Publicado: (2019)

Environmental adaptation of Acanthamoeba castellanii and Entamoeba histolytica at genome level as seen by comparative genomic analysis
por: Shabardina, Victoria, et al.
Publicado: (2018)

Comprehensive translational control of tyrosine kinase expression by upstream open reading frames
por: Wethmar, K, et al.
Publicado: (2016)

The new uORFdb: integrating literature, sequence, and variation data in a central hub for uORF research
por: Manske, Felix, et al.
Publicado: (2022)

Noise reduction by upstream open reading frames
por: Wu, Ho-Wei, et al.
Publicado: (2022)

Life cycle adapted upstream open reading frames (uORFs) in Trypanosoma congolense: A post-transcriptional approach to accurate gene regulation
por: Fervers, Philipp, et al.
Publicado: (2018)

Conserved upstream open reading frames in higher plants
por: Tran, Michael K, et al.
Publicado: (2008)

The role of upstream sequences in selecting the reading frame on tmRNA
por: Miller, Mickey R, et al.
Publicado: (2008)

Predicting functional upstream open reading frames in Saccharomyces cerevisiae
por: Selpi, et al.
Publicado: (2009)

A perspective on mammalian upstream open reading frame function
por: Somers, Joanna, et al.
Publicado: (2013)

Translational buffering by ribosome stalling in upstream open reading frames
por: Bottorff, Ty A., et al.
Publicado: (2022)

Gene Expression Regulation by Upstream Open Reading Frames and Human Disease
por: Barbosa, Cristina, et al.
Publicado: (2013)

Translation of upstream open reading frames in a model of neuronal differentiation
por: Rodriguez, Caitlin M., et al.
Publicado: (2019)

Temperature-dependent regulation of upstream open reading frame translation in S. cerevisiae
por: Kulkarni, Shardul D., et al.
Publicado: (2019)

Posttranscriptional Regulation by Copper with a New Upstream Open Reading Frame
por: Roy, Gauthier, et al.
Publicado: (2022)

Conserved Peptide Upstream Open Reading Frames are Associated with Regulatory Genes in Angiosperms
por: Jorgensen, Richard A., et al.
Publicado: (2012)

Extensive Transcript Diversity and Novel Upstream Open Reading Frame Regulation in Yeast
por: Waern, Karl, et al.
Publicado: (2013)

Selective Constraint on the Upstream Open Reading Frames That Overlap with Coding Sequences in Animals
por: Hsu, Ming-Kung, et al.
Publicado: (2012)

A comprehensive catalog of predicted functional upstream open reading frames in humans
por: McGillivray, Patrick, et al.
Publicado: (2018)

Translational control of murine adiponectin expression by an upstream open reading frame element
por: Vasu, Kommireddy, et al.
Publicado: (2023)

CHARGE syndrome due to deletion of region upstream of CHD7 gene START codon
por: Pisaneschi, Elisa, et al.
Publicado: (2015)

A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation
por: Ivanov, Ivaylo P., et al.
Publicado: (2010)

An Upstream Open Reading Frame Modulates Ebola Virus Polymerase Translation and Virus Replication
por: Shabman, Reed S., et al.
Publicado: (2013)

Translation of the human erythropoietin transcript is regulated by an upstream open reading frame in response to hypoxia
por: Barbosa, Cristina, et al.
Publicado: (2014)

An Upstream Open Reading Frame Regulates LST1 Expression during Monocyte Differentiation
por: Schiller, Christian, et al.
Publicado: (2014)

uORF-Tools—Workflow for the determination of translation-regulatory upstream open reading frames
por: Scholz, Anica, et al.
Publicado: (2019)

Variation in upstream open reading frames contributes to allelic diversity in maize protein abundance
por: Gage, Joseph L., et al.
Publicado: (2022)

Premature termination codons are recognized in the nucleus in a reading-frame-dependent manner
por: Shi, Min, et al.
Publicado: (2015)

Evidence for conservation and selection of upstream open reading frames suggests probable encoding of bioactive peptides
por: Crowe, Mark L, et al.
Publicado: (2006)

uPEPperoni: An online tool for upstream open reading frame location and analysis of transcript conservation
por: Skarshewski, Adam, et al.
Publicado: (2014)

An Upstream Open Reading Frame Represses Translation of Chicken PPARγ Transcript Variant 1
por: Chu, Yankai, et al.
Publicado: (2020)

Application of Upstream Open Reading Frames (uORFs) Editing for the Development of Stress-Tolerant Crops
por: Um, Taeyoung, et al.
Publicado: (2021)

Translation of ABCE1 Is Tightly Regulated by Upstream Open Reading Frames in Human Colorectal Cells
por: Silva, Joana, et al.
Publicado: (2021)

Upstream Open Reading Frame Mediated Translation of WNK8 Is Required for ABA Response in Arabidopsis
por: Li, Zhiyong, et al.
Publicado: (2021)

Common and Rare 5′UTR Variants Altering Upstream Open Reading Frames in Cardiovascular Genomics
por: Soukarieh, Omar, et al.
Publicado: (2022)

uORF4u: a tool for annotation of conserved upstream open reading frames
por: Egorov, Artyom A, et al.
Publicado: (2023)

Introducing COCOS: codon consequence scanner for annotating reading frame changes induced by stop-lost and frame shift variants
por: Butkiewicz, Mariusz, et al.
Publicado: (2017)

tRNA properties help shape codon pair preferences in open reading frames
por: Buchan, J. Ross, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_12roqgo549eu2vn02c6sidr0pb