Regulation of AMPK Activity by CRBN Is Independent of the Thalidomide-CRL4(CRBN) Protein Degradation Axis

Cereblon (CRBN), a primary target of immune-modulatory imide drugs (IMiDs), functions as a substrate receptor in the CUL4-RBX1-DDB1-CRBN (known as CRL4(CRBN)) E3 ubiquitin ligase complex. Binding of IMiDs to CRBN redirects the CRL4(CRBN) E3 ubiquitin ligase to recruit or displace its substrates. Int...

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Detalles Bibliográficos
Autores principales: Yang, Seung-Joo, Jeon, Seungje, Baek, Jeong Won, Lee, Kwang Min, Park, Chul-Seung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228114/
https://www.ncbi.nlm.nih.gov/pubmed/34073624
http://dx.doi.org/10.3390/ph14060512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228114/
https://www.ncbi.nlm.nih.gov/pubmed/34073624
http://dx.doi.org/10.3390/ph14060512

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