Cargando…

Regulation of AMPK Activity by CRBN Is Independent of the Thalidomide-CRL4(CRBN) Protein Degradation Axis

Cereblon (CRBN), a primary target of immune-modulatory imide drugs (IMiDs), functions as a substrate receptor in the CUL4-RBX1-DDB1-CRBN (known as CRL4(CRBN)) E3 ubiquitin ligase complex. Binding of IMiDs to CRBN redirects the CRL4(CRBN) E3 ubiquitin ligase to recruit or displace its substrates. Int...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Seung-Joo, Jeon, Seungje, Baek, Jeong Won, Lee, Kwang Min, Park, Chul-Seung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228114/ https://www.ncbi.nlm.nih.gov/pubmed/34073624 http://dx.doi.org/10.3390/ph14060512

Ejemplares similares

Ablation of CRBN induces loss of type I collagen and SCH in mouse skin by fibroblast senescence via the p38 MAPK pathway
por: Jeon, Seungje, et al.
Publicado: (2021)

Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide
por: Fischer, Eric S., et al.
Publicado: (2014)

Thalidomide Inhibits Human iPSC Mesendoderm Differentiation by Modulating CRBN-dependent Degradation of SALL4
por: Belair, David G., et al.
Publicado: (2020)

CRL4(CRBN) E3 Ligase Complex as a Therapeutic Target in Multiple Myeloma
por: Barankiewicz, Joanna, et al.
Publicado: (2022)

Crbn modulates calcium influx by regulating Orai1 during efferocytosis
por: Moon, Hyunji, et al.
Publicado: (2020)

De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives
por: Heim, Christopher, et al.
Publicado: (2019)

Thalidomide Attenuates Mast Cell Activation by Upregulating SHP-1 Signaling and Interfering with the Action of CRBN
por: Chang, Hyeun-Wook, et al.
Publicado: (2023)

Comparative Genomics Identifies Putative Interspecies Mechanisms Underlying Crbn-Sall4-Linked Thalidomide Embryopathy
por: Kowalski, Thayne Woycinck, et al.
Publicado: (2021)

Gluconeogenic signals regulate hepcidin gene expression via a CRBN-KLF15 axis
por: Jo, Jeong-Rang, et al.
Publicado: (2021)

pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4(CRBN) ubiquitin ligase
por: An, Jian, et al.
Publicado: (2017)

Design, Synthesis, and Biological Evaluation of HDAC Degraders with CRBN E3 Ligase Ligands
por: Lu, Yingxin, et al.
Publicado: (2021)

PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates
por: Shimizu, Nobuyuki, et al.
Publicado: (2021)

Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4
por: Bjorklund, C C, et al.
Publicado: (2015)

Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN)
por: Gandhi, Anita K, et al.
Publicado: (2014)

Enhancement of the SESN2-SHP cascade by melatonin ameliorates hepatic gluconeogenesis by inhibiting the CRBN-BTG2-CREBH signaling pathway
por: An, Seungwon, et al.
Publicado: (2023)

The Relationship Between the Expression of CRBN in Peripheral Blood and the Severity and Prognosis of Adult Sepsis
por: Kuang, Zhiming, et al.
Publicado: (2023)

CRBN is downregulated in lung cancer and negatively regulates TLR2, 4 and 7 stimulation in lung cancer cells
por: Kim, Mi‐Jeong, et al.
Publicado: (2022)

CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1
por: Kim, Mi-Jeong, et al.
Publicado: (2019)

Mutations in CRBN and other cereblon pathway genes are infrequently associated with acquired resistance to immunomodulatory drugs
por: Jones, J. R., et al.
Publicado: (2021)

The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma
por: Heider, Michael, et al.
Publicado: (2021)

Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide
por: Tateno, Shumpei, et al.
Publicado: (2020)

A Cereblon Modulator CC-885 Induces CRBN- and p97-Dependent PLK1 Degradation and Synergizes with Volasertib to Suppress Lung Cancer
por: Li, Lifeng, et al.
Publicado: (2020)

Polymorphisms in the promoter region of the CRBN gene as a predictive factor for the first-line CTD therapy in multiple myeloma patients
por: Szudy-Szczyrek, Aneta, et al.
Publicado: (2018)

A missense mutation in the CRBN gene that segregates with intellectual disability and self-mutilating behaviour in a consanguineous Saudi family
por: Sheereen, Atia, et al.
Publicado: (2017)

The CRBN, CUL4A and DDB1 Expression Predicts the Response to Immunomodulatory Drugs and Survival of Multiple Myeloma Patients
por: Barankiewicz, Joanna, et al.
Publicado: (2021)

Absence of mutations in cereblon (CRBN) and DNA damage-binding protein 1 (DDB1) genes and significance for IMiD therapy
por: Thakurta, A, et al.
Publicado: (2014)

Cereblon/CRBN在弥漫大B细胞淋巴瘤中的表达及其与预后的关系
Publicado: (2020)

CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy
por: Fu, Ssu-Ju, et al.
Publicado: (2020)

CRL4-Cereblon complex in Thalidomide Embryopathy: a translational investigation
por: Kowalski, Thayne Woycinck, et al.
Publicado: (2020)

Iberdomide (CC-220) is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with dysregulated CRBN
por: Bjorklund, Chad C., et al.
Publicado: (2019)

PB1958: IN SILICO ANALYSIS OF SYNONYMOUS AND NON-SYNONYMOUS SNPS OF THE HUMAN CEREBLON (CRBN) GENE: AN IMPORTANT GENE IN IMMUNOMODULATORY DRUGS (IMIDS)-BASED TREATMENT OF MULTIPLE MYELOMA PATIENTS
por: Güler, M., et al.
Publicado: (2022)

Esco2 and cohesin regulate CRL4 ubiquitin ligase ddb1 expression and thalidomide teratogenicity
por: Sanchez, Annie C., et al.
Publicado: (2022)

Aryl Sulfonamides Induce Degradation of Aryl Hydrocarbon Receptor Nuclear Translocator through CRL4(DCAF15) E3 Ligase
por: Kim, Sung Ah, et al.
Publicado: (2020)

Chemical Degradation of Androgen Receptor (AR) Using Bicalutamide Analog–Thalidomide PROTACs
por: Kim, Ga Yeong, et al.
Publicado: (2021)

BK channel blocker paxilline attenuates thalidomide-caused synaptic and cognitive dysfunctions in mice
por: Choi, Tae-Yong, et al.
Publicado: (2018)

Thalidomide Inhibits Alternative Activation of Macrophages In Vivo and In Vitro: A Potential Mechanism of Anti-Asthmatic Effect of Thalidomide
por: Lee, Hyun Seung, et al.
Publicado: (2015)

Quantitative analyses for effects of neddylation on CRL2(VHL) substrate ubiquitination and degradation
por: Wang, Kankan, et al.
Publicado: (2021)

Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma
por: Benamar, Mouadh, et al.
Publicado: (2016)

The Neuroprotective Effect of Thalidomide against Ischemia through the Cereblon-mediated Repression of AMPK Activity
por: Sawamura, Naoya, et al.
Publicado: (2018)

Amorphigenin from Amorpha fruticosa L. Root Extract Induces Autophagy-Mediated Melanosome Degradation in mTOR-Independent- and AMPK-Dependent Manner
por: Lee, Ki Won, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2c4ptda33l54rm9f1ajlj88s85