An Engineered Maturation Cleavage Provides a Recombinant Mimic of Foot-and-Mouth Disease Virus Capsid Assembly-Disassembly

Picornavirus capsids are assembled from 60 copies of a capsid precursor via a pentameric assembly intermediate or ‘pentamer’. Upon completion of virion assembly, a maturation event induces a final cleavage of the capsid precursor to create the capsid protein VP4, which is essential for capsid stabil...

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Detalles Bibliográficos
Autores principales: Newman, Joseph, Rowlands, David J., Tuthill, Tobias J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228156/
https://www.ncbi.nlm.nih.gov/pubmed/34072387
http://dx.doi.org/10.3390/life11060500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228156/
https://www.ncbi.nlm.nih.gov/pubmed/34072387
http://dx.doi.org/10.3390/life11060500

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