Transcriptional Pausing and Activation at Exons-1 and -2, Respectively, Mediate the MGMT Gene Expression in Human Glioblastoma Cells

Background: The therapeutically important DNA repair gene O(6)-methylguanine DNA methyltransferase (MGMT) is silenced by promoter methylation in human brain cancers. The co-players/regulators associated with this process and the subsequent progression of MGMT gene transcription beyond the non-coding...

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Detalles Bibliográficos
Autores principales: Al-Obaide, Mohammed A. Ibrahim, Srivenugopal, Kalkunte S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228370/
https://www.ncbi.nlm.nih.gov/pubmed/34201219
http://dx.doi.org/10.3390/genes12060888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228370/
https://www.ncbi.nlm.nih.gov/pubmed/34201219
http://dx.doi.org/10.3390/genes12060888

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