Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells

The association between intratumoral cholesteryl ester (CE) and tumor progression has been reported previously. The objective of our study was to investigate a causal effect of CE on mammary tumor progression. Using MMTV-PyMT (MMTV-polyoma virus middle T) transgenic mice and breast tumor cell MCF-7,...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Lengyun, Lu, Xuyang, Weng, Shengmei, Zhu, Shenglong, Chen, Yongquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228430/
https://www.ncbi.nlm.nih.gov/pubmed/34201030
http://dx.doi.org/10.3390/biom11060853
_version_ 1783712741598429184
author Wei, Lengyun
Lu, Xuyang
Weng, Shengmei
Zhu, Shenglong
Chen, Yongquan
author_facet Wei, Lengyun
Lu, Xuyang
Weng, Shengmei
Zhu, Shenglong
Chen, Yongquan
author_sort Wei, Lengyun
collection PubMed
description The association between intratumoral cholesteryl ester (CE) and tumor progression has been reported previously. The objective of our study was to investigate a causal effect of CE on mammary tumor progression. Using MMTV-PyMT (MMTV-polyoma virus middle T) transgenic mice and breast tumor cell MCF-7, we show that both exogenous and endogenous CE can increase mammary tumor growth, that CE upregulates the AKT/mTOR pathway, and that CE synthesis blockade suppresses this signaling pathway. Our data suggest that SOAT1, a sterol O-acyltransferase, may be a potential target for the treatment of breast cancer.
format Online
Article
Text
id pubmed-8228430
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82284302021-06-26 Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells Wei, Lengyun Lu, Xuyang Weng, Shengmei Zhu, Shenglong Chen, Yongquan Biomolecules Article The association between intratumoral cholesteryl ester (CE) and tumor progression has been reported previously. The objective of our study was to investigate a causal effect of CE on mammary tumor progression. Using MMTV-PyMT (MMTV-polyoma virus middle T) transgenic mice and breast tumor cell MCF-7, we show that both exogenous and endogenous CE can increase mammary tumor growth, that CE upregulates the AKT/mTOR pathway, and that CE synthesis blockade suppresses this signaling pathway. Our data suggest that SOAT1, a sterol O-acyltransferase, may be a potential target for the treatment of breast cancer. MDPI 2021-06-08 /pmc/articles/PMC8228430/ /pubmed/34201030 http://dx.doi.org/10.3390/biom11060853 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wei, Lengyun
Lu, Xuyang
Weng, Shengmei
Zhu, Shenglong
Chen, Yongquan
Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells
title Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells
title_full Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells
title_fullStr Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells
title_full_unstemmed Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells
title_short Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells
title_sort cholesteryl ester promotes mammary tumor growth in mmtv-pymt mice and activates akt-mtor pathway in tumor cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228430/
https://www.ncbi.nlm.nih.gov/pubmed/34201030
http://dx.doi.org/10.3390/biom11060853
work_keys_str_mv AT weilengyun cholesterylesterpromotesmammarytumorgrowthinmmtvpymtmiceandactivatesaktmtorpathwayintumorcells
AT luxuyang cholesterylesterpromotesmammarytumorgrowthinmmtvpymtmiceandactivatesaktmtorpathwayintumorcells
AT wengshengmei cholesterylesterpromotesmammarytumorgrowthinmmtvpymtmiceandactivatesaktmtorpathwayintumorcells
AT zhushenglong cholesterylesterpromotesmammarytumorgrowthinmmtvpymtmiceandactivatesaktmtorpathwayintumorcells
AT chenyongquan cholesterylesterpromotesmammarytumorgrowthinmmtvpymtmiceandactivatesaktmtorpathwayintumorcells

Ejemplares similares