Cargando…

Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells

The association between intratumoral cholesteryl ester (CE) and tumor progression has been reported previously. The objective of our study was to investigate a causal effect of CE on mammary tumor progression. Using MMTV-PyMT (MMTV-polyoma virus middle T) transgenic mice and breast tumor cell MCF-7,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, Lengyun, Lu, Xuyang, Weng, Shengmei, Zhu, Shenglong, Chen, Yongquan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228430/ https://www.ncbi.nlm.nih.gov/pubmed/34201030 http://dx.doi.org/10.3390/biom11060853

Ejemplares similares

A PDE Model of Breast Tumor Progression in MMTV-PyMT Mice
por: Mohammad Mirzaei, Navid, et al.
Publicado: (2022)

Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model
por: Roselli, Séverine, et al.
Publicado: (2014)

Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice
por: Decock, Julie, et al.
Publicado: (2015)

Transcriptomic dynamics of breast cancer progression in the MMTV-PyMT mouse model
por: Cai, Ying, et al.
Publicado: (2017)

MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model
por: Kwa, Mei Qi, et al.
Publicado: (2021)

Biomarkers of Residual Disease, Disseminated Tumor Cells, and Metastases in the MMTV-PyMT Breast Cancer Model
por: Franci, Christian, et al.
Publicado: (2013)

Investigating the Role of Heparanase in Breast Cancer Development Utilising the MMTV-PyMT Murine Model of Mammary Carcinoma
por: Jayatilleke, Krishnath M., et al.
Publicado: (2023)

Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells
por: Boyle, Sarah T., et al.
Publicado: (2017)

The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages
por: Boyle, Sarah T., et al.
Publicado: (2015)

Anti-matrix metalloproteinase-9 DNAzyme decreases tumor growth in the MMTV-PyMT mouse model of breast cancer
por: Hallett, Miranda A, et al.
Publicado: (2013)

Apc Mutation Enhances PyMT-Induced Mammary Tumorigenesis
por: Prosperi, Jenifer R., et al.
Publicado: (2011)

High-Fat, High-Calorie Diet Enhances Mammary Carcinogenesis and Local Inflammation in MMTV-PyMT Mouse Model of Breast Cancer
por: Cowen, Sarah, et al.
Publicado: (2015)

Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan
por: Gibby, Krissa, et al.
Publicado: (2012)

Treatment response assessment with (R)-[(11)CPAQ PET in the MMTV-PyMT mouse model of breast cancer
por: Tegnebratt, T., et al.
Publicado: (2018)

A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer
por: Velazquez, Fabiola N., et al.
Publicado: (2021)

Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer
por: Velazquez, Fabiola N., et al.
Publicado: (2021)

Chronic Stress Exposure Suppresses Mammary Tumor Growth and Reduces Circulating Exosome TGF-β Content via β-Adrenergic Receptor Signaling in MMTV-PyMT Mice
por: Dawes, Ryan P, et al.
Publicado: (2020)

S100A10 Has a Critical Regulatory Function in Mammary Tumor Growth and Metastasis: Insights Using MMTV-PyMT Oncomice and Clinical Patient Sample Analysis
por: Bharadwaj, Alamelu G., et al.
Publicado: (2020)

No Effect of NGAL/lipocalin-2 on Aggressiveness of Cancer in the MMTV-PyMT/FVB/N Mouse Model for Breast Cancer
por: Cramer, Elisabeth P., et al.
Publicado: (2012)

Mammary Tumorigenesis and Metabolome in Male Adipose Specific Monocyte Chemotactic Protein-1 Deficient MMTV-PyMT Mice Fed a High-Fat Diet
por: Yan, Lin, et al.
Publicado: (2021)

Deletion of Col15a1 Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the MMTV-PyMT Mouse Mammary Carcinoma Model
por: Martínez-Nieto, Guillermo, et al.
Publicado: (2021)

Immune Checkpoint Blockade Improves Chemotherapy in the PyMT Mammary Carcinoma Mouse Model
por: Sirait-Fischer, Evelyn, et al.
Publicado: (2020)

Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model
por: Otsuka, Yutaro, et al.
Publicado: (2018)

GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer
por: Lynn, Kristi D, et al.
Publicado: (2010)

Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice
por: Aboouf, Mostafa A., et al.
Publicado: (2023)

Characterization of Mammary Tumors Arising from MMTV-PyVT Transgenic Mice
por: Liu, Chien-Liang, et al.
Publicado: (2023)

RHAMM regulates MMTV-PyMT-induced lung metastasis by connecting STING-dependent DNA damage sensing to interferon/STAT1 pro-apoptosis signaling
por: Tolg, Cornelia, et al.
Publicado: (2023)

Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential
por: Cordero, Alex, et al.
Publicado: (2023)

Correction to: Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential
por: Cordero, Alex, et al.
Publicado: (2023)

PyMT-1099, a versatile murine cell model for EMT in breast cancer
por: Saxena, Meera, et al.
Publicado: (2018)

Breast tumors in PyMT transgenic mice expressing mitochondrial catalase have decreased labeling for macrophages and endothelial cells
por: Fatemie, Sy, et al.
Publicado: (2012)

Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer
por: Roy, Lopamudra Das, et al.
Publicado: (2011)

High folic acid diet enhances tumour growth in PyMT-induced breast cancer
por: Hansen, Mariann Fagernæs, et al.
Publicado: (2017)

Ovarian cycle stage critically affects 21-gene recurrence scores in Mmtv-Pymt mouse mammary tumours
por: Bernhardt, Sarah M., et al.
Publicado: (2021)

PyMT-Maclow: A novel, inducible, murine model for determining the role of CD68 positive cells in breast tumor development
por: Rumney, Robin M. H., et al.
Publicado: (2017)

MicroRNA expression and gene regulation drive breast cancer progression and metastasis in PyMT mice
por: Nogales-Cadenas, Ruben, et al.
Publicado: (2016)

Author Correction: PyMT-1099, a versatile murine cell model for EMT in breast cancer
por: Saxena, Meera, et al.
Publicado: (2020)

Adiponectin Haploinsufficiency Promotes Mammary Tumor Development in MMTV-PyVT Mice by Modulation of Phosphatase and Tensin Homolog Activities
por: Lam, Janice B. B., et al.
Publicado: (2009)

FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors
por: Paul, Ritama, et al.
Publicado: (2020)

Correction: Adiponectin Haploinsufficiency Promotes Mammary Tumor Development in MMTV-PyVT Mice by Modulation of Phosphatase and Tensin Homolog Activities
por: Lam, Janice B. B., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_43ng3473r37e4jnrl14rcgresq