Effect of Genetic Variability in 20 Pharmacogenes on Concentrations of Tamoxifen and Its Metabolites

Background: Tamoxifen, as a treatment of estrogen receptor positive (ER+) breast cancer, is a weak anti-estrogen that requires metabolic activation to form metabolites with higher anti-estrogenic activity. Endoxifen is the most-studied active tamoxifen metabolite, and endoxifen concentrations are hi...

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Detalles Bibliográficos
Autores principales: Chen, Yuanhuang, Marcath, Lauren A., Eliassen, Finn Magnus, Lende, Tone Hoel, Soiland, Havard, Mellgren, Gunnar, Helland, Thomas, Hertz, Daniel Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228634/
https://www.ncbi.nlm.nih.gov/pubmed/34199712
http://dx.doi.org/10.3390/jpm11060507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228634/
https://www.ncbi.nlm.nih.gov/pubmed/34199712
http://dx.doi.org/10.3390/jpm11060507

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