Model-Informed Optimization of a Pediatric Clinical Pharmacokinetic Trial of a New Spironolactone Liquid Formulation

Quantitative pharmacology brings important advantages in the design and conduct of pediatric clinical trials. Herein, we demonstrate the application of a model-based approach to select doses and pharmacokinetic sampling scenarios for the clinical evaluation of a novel oral suspension of spironolacto...

Descripción completa

Detalles Bibliográficos
Autores principales: Tatipalli, Manasa, Siripuram, Vijay Kumar, Long, Tao, Shuster, Diana, Bernstein, Galina, Martineau, Pierre, Cook, Kim A., Cristofoletti, Rodrigo, Schmidt, Stephan, Vozmediano, Valvanera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228864/
https://www.ncbi.nlm.nih.gov/pubmed/34201093
http://dx.doi.org/10.3390/pharmaceutics13060849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228864/
https://www.ncbi.nlm.nih.gov/pubmed/34201093
http://dx.doi.org/10.3390/pharmaceutics13060849

Ejemplares similares