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Model-Informed Optimization of a Pediatric Clinical Pharmacokinetic Trial of a New Spironolactone Liquid Formulation

Quantitative pharmacology brings important advantages in the design and conduct of pediatric clinical trials. Herein, we demonstrate the application of a model-based approach to select doses and pharmacokinetic sampling scenarios for the clinical evaluation of a novel oral suspension of spironolacto...

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Detalles Bibliográficos
Autores principales:	Tatipalli, Manasa, Siripuram, Vijay Kumar, Long, Tao, Shuster, Diana, Bernstein, Galina, Martineau, Pierre, Cook, Kim A., Cristofoletti, Rodrigo, Schmidt, Stephan, Vozmediano, Valvanera
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228864/ https://www.ncbi.nlm.nih.gov/pubmed/34201093 http://dx.doi.org/10.3390/pharmaceutics13060849

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