Phytochemical and Ethnopharmacological Perspectives of Ehretia laevis

Ehretia laevis Roxb. (Boraginaceae) has been extensively used as a traditional remedy for the treatment of a diverse range of ailments related to the respiratory system, the gastrointestinal tract, the reproductive system, and against several infections. This review critically assesses and documents...

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Autores principales: Sharma, Pooja, Shri, Richa, Ntie-Kang, Fidele, Kumar, Suresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228998/
https://www.ncbi.nlm.nih.gov/pubmed/34201193
http://dx.doi.org/10.3390/molecules26123489
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author Sharma, Pooja
Shri, Richa
Ntie-Kang, Fidele
Kumar, Suresh
author_facet Sharma, Pooja
Shri, Richa
Ntie-Kang, Fidele
Kumar, Suresh
author_sort Sharma, Pooja
collection PubMed
description Ehretia laevis Roxb. (Boraginaceae) has been extensively used as a traditional remedy for the treatment of a diverse range of ailments related to the respiratory system, the gastrointestinal tract, the reproductive system, and against several infections. This review critically assesses and documents, for the first time, the fragmented information on E. laevis, including its botanical description, folklore uses, bioactive phyto metabolites and pharmacological activities. The goal is to explore this plant therapeutically. Ethnomedicinal surveys reveal that E. laevis has been used by tribal communities in Asian countries for the treatment of various disorders. Quantitative and qualitative phytochemical investigations of E. laevis showed the presence of important phytoconstituents such as pentacyclic triterpenoids, phenolic acids, flavonoids, fatty acids, steroids, alkaloids, aliphatic alcohols, hydrocarbons, amino acids, carbohydrates, vitamins and minerals. Fresh plant parts, crude extracts, fractions and isolated compounds have been reported to exhibit broad spectrum of therapeutic activities viz., antioxidant, antiarthritic, antidiabetic, anti-inflammatory, antiulcer, antidiarrheal, antidysenteric, wound healing and anti-infective activities. E. laevis is shown to be an excellent potential source of drugs for the mitigation of jaundice, asthma, dysentery, ulcers, diarrhea, ringworm, eczema, diabetes, fissure, syphilis, cuts and wounds, inflammation, liver problems, venereal and infectious disorders. Although few investigations authenticated its traditional uses but employed uncharacterized crude extracts of the plant, the major concerns raised are reproducibility of therapeutic efficacy and safety of plant material. The outcomes of limited pharmacological screening and reported bioactive compounds of E. laevis suggest that there is an urgent need for in-depth pharmacological investigations of the plant.
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spelling pubmed-82289982021-06-26 Phytochemical and Ethnopharmacological Perspectives of Ehretia laevis Sharma, Pooja Shri, Richa Ntie-Kang, Fidele Kumar, Suresh Molecules Review Ehretia laevis Roxb. (Boraginaceae) has been extensively used as a traditional remedy for the treatment of a diverse range of ailments related to the respiratory system, the gastrointestinal tract, the reproductive system, and against several infections. This review critically assesses and documents, for the first time, the fragmented information on E. laevis, including its botanical description, folklore uses, bioactive phyto metabolites and pharmacological activities. The goal is to explore this plant therapeutically. Ethnomedicinal surveys reveal that E. laevis has been used by tribal communities in Asian countries for the treatment of various disorders. Quantitative and qualitative phytochemical investigations of E. laevis showed the presence of important phytoconstituents such as pentacyclic triterpenoids, phenolic acids, flavonoids, fatty acids, steroids, alkaloids, aliphatic alcohols, hydrocarbons, amino acids, carbohydrates, vitamins and minerals. Fresh plant parts, crude extracts, fractions and isolated compounds have been reported to exhibit broad spectrum of therapeutic activities viz., antioxidant, antiarthritic, antidiabetic, anti-inflammatory, antiulcer, antidiarrheal, antidysenteric, wound healing and anti-infective activities. E. laevis is shown to be an excellent potential source of drugs for the mitigation of jaundice, asthma, dysentery, ulcers, diarrhea, ringworm, eczema, diabetes, fissure, syphilis, cuts and wounds, inflammation, liver problems, venereal and infectious disorders. Although few investigations authenticated its traditional uses but employed uncharacterized crude extracts of the plant, the major concerns raised are reproducibility of therapeutic efficacy and safety of plant material. The outcomes of limited pharmacological screening and reported bioactive compounds of E. laevis suggest that there is an urgent need for in-depth pharmacological investigations of the plant. MDPI 2021-06-08 /pmc/articles/PMC8228998/ /pubmed/34201193 http://dx.doi.org/10.3390/molecules26123489 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sharma, Pooja
Shri, Richa
Ntie-Kang, Fidele
Kumar, Suresh
Phytochemical and Ethnopharmacological Perspectives of Ehretia laevis
title Phytochemical and Ethnopharmacological Perspectives of Ehretia laevis
title_full Phytochemical and Ethnopharmacological Perspectives of Ehretia laevis
title_fullStr Phytochemical and Ethnopharmacological Perspectives of Ehretia laevis
title_full_unstemmed Phytochemical and Ethnopharmacological Perspectives of Ehretia laevis
title_short Phytochemical and Ethnopharmacological Perspectives of Ehretia laevis
title_sort phytochemical and ethnopharmacological perspectives of ehretia laevis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228998/
https://www.ncbi.nlm.nih.gov/pubmed/34201193
http://dx.doi.org/10.3390/molecules26123489
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