Time-Resolved Effect of Interferon-Alpha 2a on Activities of Nuclear Factor Kappa B, Pregnane X Receptor and on Drug Disposition Genes

Interferon-alpha (IFN-α) is suggested to cause pharmacokinetic drug interactions by lowering expression of drug disposition genes through affecting the activities of nuclear factor kappa B (NF-ĸB) and pregnane X receptor (PXR). The time-resolved impact of IFN-α 2a (1000 U/mL; 5000 U/mL; 2 h to 30 h)...

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Detalles Bibliográficos
Autores principales: Theile, Dirk, Wagner, Lelia, Bay, Cindy, Haefeli, Walter Emil, Weiss, Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229072/
https://www.ncbi.nlm.nih.gov/pubmed/34071580
http://dx.doi.org/10.3390/pharmaceutics13060808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229072/
https://www.ncbi.nlm.nih.gov/pubmed/34071580
http://dx.doi.org/10.3390/pharmaceutics13060808

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