ACE2-Independent Interaction of SARS-CoV-2 Spike Protein with Human Epithelial Cells Is Inhibited by Unfractionated Heparin

Coronaviruses such as SARS-CoV-2, which is responsible for COVID-19, depend on virus spike protein binding to host cell receptors to cause infection. The SARS-CoV-2 spike protein binds primarily to ACE2 on target cells and is then processed by membrane proteases, including TMPRSS2, leading to viral...

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Detalles Bibliográficos
Autores principales: Partridge, Lynda J., Urwin, Lucy, Nicklin, Martin J. H., James, David C., Green, Luke R., Monk, Peter N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229176/
https://www.ncbi.nlm.nih.gov/pubmed/34200372
http://dx.doi.org/10.3390/cells10061419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229176/
https://www.ncbi.nlm.nih.gov/pubmed/34200372
http://dx.doi.org/10.3390/cells10061419

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