Towards a New, Endophenotype-Based Strategy for Pathogenicity Prediction in BRCA1 and BRCA2: In Silico Modeling of the Outcome of HDR/SGE Assays for Missense Variants

The present limitations in the pathogenicity prediction of BRCA1 and BRCA2 (BRCA1/2) missense variants constitute an important problem with negative consequences for the diagnosis of hereditary breast and ovarian cancer. However, it has been proposed that the use of endophenotype predictions, i.e.,...

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Detalles Bibliográficos
Autores principales: Özkan, Selen, Padilla, Natàlia, de la Cruz, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229251/
https://www.ncbi.nlm.nih.gov/pubmed/34207612
http://dx.doi.org/10.3390/ijms22126226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229251/
https://www.ncbi.nlm.nih.gov/pubmed/34207612
http://dx.doi.org/10.3390/ijms22126226

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