In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone in Leishmania spp.

Epoxy-α-lapachone (Lap) and Epoxymethyl-lawsone (Law) are oxiranes derived from Lapachol and have been shown to be promising drugs for Leishmaniases treatment. Although, it is known the action spectrum of both compounds affect the Leishmania spp. multiplication, there are gaps in the molecular bindi...

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Detalles Bibliográficos
Autores principales: Peixoto, Juliana Figueiredo, Oliveira, Adriane da Silva, Monteiro, Patrícia Queiroz, Gonçalves-Oliveira, Luiz Filipe, Andrade-Neto, Valter Viana, Ferreira, Vitor Francisco, Souza-Silva, Franklin, Alves, Carlos Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229338/
https://www.ncbi.nlm.nih.gov/pubmed/34200517
http://dx.doi.org/10.3390/molecules26123537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229338/
https://www.ncbi.nlm.nih.gov/pubmed/34200517
http://dx.doi.org/10.3390/molecules26123537

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