The NHance(®) Mutation-Equipped Anti-MET Antibody ARGX-111 Displays Increased Tissue Penetration and Anti-Tumor Activity in Advanced Cancer Patients

Dysregulation of MET signaling has been implicated in tumorigenesis and metastasis. ARGX-111 combines complete blockade of this pathway with enhanced tumor cell killing and was investigated in 24 patients with MET-positive advanced cancers in a phase 1b study at four dose levels (0.3–10 mg/kg). ARGX...

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Detalles Bibliográficos
Autores principales: Aftimos, Philippe, Rolfo, Christian, Rottey, Sylvie, Barthélémy, Philippe, Borg, Christophe, Park, Keunchil, Oh, Do-Youn, Kim, Sang-We, De Jonge, Natalie, Hanssens, Valérie, Zwanenpoel, Karen, Molthoff, Carla, Vugts, Daniëlle, Dreier, Torsten, Verheesen, Peter, van Dongen, Guus A.M.S., Jacobs, Julie, Van Rompaey, Luc, Hultberg, Anna, Michieli, Paolo, Pauwels, Patrick, Fung, Samson, Thibault, Alain, de Haard, Hans, Leupin, Nicolas, Awada, Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229762/
https://www.ncbi.nlm.nih.gov/pubmed/34200749
http://dx.doi.org/10.3390/biomedicines9060665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229762/
https://www.ncbi.nlm.nih.gov/pubmed/34200749
http://dx.doi.org/10.3390/biomedicines9060665

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