Decreased Substrate Stiffness Promotes a Hypofibrotic Phenotype in Cardiac Fibroblasts

A hypofibrotic phenotype has been observed in cardiac fibroblasts (CFs) isolated from a volume overload heart failure model, aortocaval fistula (ACF). This paradoxical phenotype results in decreased ECM synthesis despite increased TGF-β presence. Since ACF results in decreased tissue stiffness relat...

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Detalles Bibliográficos
Autores principales: Childers, Rachel C., Lucchesi, Pamela A., Gooch, Keith J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230133/
https://www.ncbi.nlm.nih.gov/pubmed/34207723
http://dx.doi.org/10.3390/ijms22126231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230133/
https://www.ncbi.nlm.nih.gov/pubmed/34207723
http://dx.doi.org/10.3390/ijms22126231

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