Dapagliflozin Restores Impaired Autophagy and Suppresses Inflammation in High Glucose-Treated HK-2 Cells

Sodium-glucose cotransporter2 (SGLT2) inhibitors have a reno-protective effect in diabetic kidney disease. However, the detailed mechanism remains unclear. In this study, human proximal tubular cells (HK-2) were cultured in 5 mM glucose and 25 mM mannitol (control), 30 mM glucose (high glucose: HG),...

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Detalles Bibliográficos
Autores principales: Xu, Jing, Kitada, Munehiro, Ogura, Yoshio, Liu, Haijie, Koya, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230404/
https://www.ncbi.nlm.nih.gov/pubmed/34200774
http://dx.doi.org/10.3390/cells10061457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230404/
https://www.ncbi.nlm.nih.gov/pubmed/34200774
http://dx.doi.org/10.3390/cells10061457

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