Synthesis of Novel Acyl Derivatives of 3-(4,5,6,7-Tetrabromo-1H-benzimidazol-1-yl)propan-1-ols—Intracellular TBBi-Based CK2 Inhibitors with Proapoptotic Properties

Protein kinase CK2 has been considered as an attractive drug target for anti-cancer therapy. The synthesis of N-hydroxypropyl TBBi and 2MeTBBi derivatives as well as their respective esters was carried out by using chemoenzymatic methods. Concomitantly with kinetic studies toward recombinant CK2, th...

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Detalles Bibliográficos
Autores principales: Chojnacki, Konrad, Wińska, Patrycja, Karatsai, Olena, Koronkiewicz, Mirosława, Milner-Krawczyk, Małgorzata, Wielechowska, Monika, Rędowicz, Maria Jolanta, Bretner, Maria, Borowiecki, Paweł
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230474/
https://www.ncbi.nlm.nih.gov/pubmed/34200807
http://dx.doi.org/10.3390/ijms22126261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230474/
https://www.ncbi.nlm.nih.gov/pubmed/34200807
http://dx.doi.org/10.3390/ijms22126261

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