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Evaluation of the effects of the T-type calcium channel enhancer SAK3 in a rat model of TAF1 deficiency

The TATA-box binding protein associated factor 1 (TAF1) is part of the TFIID complex that plays a key role during the initiation of transcription. Variants of TAF1 are associated with neurodevelopmental disorders. Previously, we found that CRISPR/Cas9 based editing of the TAF1 gene disrupts the morp...

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Detalles Bibliográficos
Autores principales: Dhanalakshmi, Chinnasamy, Janakiraman, Udaiyappan, Moutal, Aubin, Fukunaga, Kohji, Khanna, Rajesh, Nelson, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230513/
https://www.ncbi.nlm.nih.gov/pubmed/33359140
http://dx.doi.org/10.1016/j.nbd.2020.105224