Cargando…

MPLA and AddaVax(®) Adjuvants Fail to Promote Intramuscular LaAg Vaccine Protectiveness against Experimental Cutaneous Leishmaniasis

There is so far no vaccine approved for human leishmaniasis, mainly because of the lack of appropriate adjuvants. This study aimed to evaluate in mice the capacity of a mixture of monophosphoryl lipid A (MPLA) and AddaVax(®) adjuvants in enhancing the efficacy of a Leishvacin(®)-like vaccine compris...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oliveira-Maciel, Diogo, dos-Santos, Júlio Souza, Oliveira-Silva, Gabriel, de Mello, Mirian França, da Fonseca-Martins, Alessandra Marcia, Carneiro, Monique Pacheco Duarte, Ramos, Tadeu Diniz, Firmino-Cruz, Luan, Gomes, Daniel Claudio Oliveira, Rossi-Bergmann, Bartira, de Matos Guedes, Herbert Leonel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230739/ https://www.ncbi.nlm.nih.gov/pubmed/34207948 http://dx.doi.org/10.3390/microorganisms9061272

Ejemplares similares

Kinetic of the Antibody Response Following AddaVax-Adjuvanted Immunization with Recombinant Influenza Antigens
por: Ross, Ted. M., et al.
Publicado: (2022)

Efficacy of intranasal LaAg vaccine against Leishmania amazonensis infection in partially resistant C57Bl/6 mice
por: Pratti, Juliana Elena Silveira, et al.
Publicado: (2016)

Formulation of an ovarian cancer vaccine with the squalene-based AddaVax adjuvant inhibits the growth of murine epithelial ovarian carcinomas
por: Mazumder, Suparna, et al.
Publicado: (2022)

The role of TLR9 on Leishmania amazonensis infection and its influence on intranasal LaAg vaccine efficacy
por: Pratti, Juliana Elena Silveira, et al.
Publicado: (2019)

Adjuvanted Schistosoma mansoni-Cathepsin B With Sulfated Lactosyl Archaeol Archaeosomes or AddaVax™ Provides Protection in a Pre-Clinical Schistosomiasis Model
por: Perera, Dilhan J., et al.
Publicado: (2020)

AddaVax-Adjuvanted H5N8 Inactivated Vaccine Induces Robust Humoral Immune Response against Different Clades of H5 Viruses
por: Gao, Feixia, et al.
Publicado: (2022)

The adjuvant AlhydroGel elicits higher antibody titres than AddaVax when combined with HIV-1 subtype C gp140 from CAP256
por: van Diepen, Michiel T., et al.
Publicado: (2018)

AddaVax Formulated with PolyI:C as a Potential Adjuvant of MDCK-based Influenza Vaccine Enhances Local, Cellular, and Antibody Protective Immune Response in Mice
por: Nian, Xuanxuan, et al.
Publicado: (2021)

Intradermal Immunization of SARS-CoV-2 Original Strain Trimeric Spike Protein Associated to CpG and AddaS03 Adjuvants, but Not MPL, Provide Strong Humoral and Cellular Response in Mice
por: Firmino-Cruz, Luan, et al.
Publicado: (2022)

Dietary Vitamin D3 Deficiency Increases Resistance to Leishmania (Leishmania) amazonensis Infection in Mice
por: Bezerra, Izabella Pereira da Silva, et al.
Publicado: (2019)

ADDA: a domain database with global coverage of the protein universe
por: Heger, Andreas, et al.
Publicado: (2005)

Characterization of Sv129 Mice as a Susceptible Model to Leishmania amazonensis
por: dos-Santos, Júlio Souza, et al.
Publicado: (2019)

Addition of daptomycin for the treatment of pneumococcal meningitis: protocol for the AddaMAP study
por: Chavanet, Pascal, et al.
Publicado: (2023)

Effects of Bone Marrow Mesenchymal Stromal Cell Therapy in Experimental Cutaneous Leishmaniasis in BALB/c Mice Induced by Leishmania amazonensis
por: Pereira, Joyce Carvalho, et al.
Publicado: (2017)

MPLA Case 3: Don’t criticize me in public!
por: Hendrickson, Kristi, et al.
Publicado: (2021)

Combined therapy with adipose tissue-derived mesenchymal stromal cells and meglumine antimoniate controls lesion development and parasite load in murine cutaneous leishmaniasis caused by Leishmania amazonensis
por: Ramos, Tadeu Diniz, et al.
Publicado: (2020)

Analysis of total microcystins and nodularins by oxidative cleavage of their ADMAdda, DMAdda, and Adda moieties
por: Foss, Amanda J., et al.
Publicado: (2020)

Introduction of Medical Physics Leadership Academy (MPLA) case studies
por: Gronberg, Mary, et al.
Publicado: (2021)

MPLA Case 4: A physicist’s consult with a patient
por: Xu, Lee, et al.
Publicado: (2021)

MPLA case: I didn't realize those were the expectations!
por: Simiele, Samantha J., et al.
Publicado: (2023)

Monophosphoryl-Lipid A (MPLA) is an Efficacious Adjuvant for Inactivated Rabies Vaccines
por: Chen, Chen, et al.
Publicado: (2019)

MPLA case: How do you lead as a lead physicist?
por: Sansourekidou, Patricia, et al.
Publicado: (2023)

HealVax
por: Foerster, John, et al.
Publicado: (2018)

Regulation of Tolerogenic Features on Dexamethasone-Modulated MPLA-Activated Dendritic Cells by MYC
por: García-González, Paulina A., et al.
Publicado: (2019)

MPLA Case 1: Implementing Cone‐Beam CT in a Community Hospital
por: Wang, Dongxu, et al.
Publicado: (2021)

MPLA Case 2: A junior physicist attempts to improve radiotherapy workflow
por: Wang, Dongxu, et al.
Publicado: (2021)

Modulation of dendritic cell metabolism by an MPLA-adjuvanted allergen product for specific immunotherapy
por: Zimmermann, Jennifer, et al.
Publicado: (2022)

To vax or not to vax: Predictors of anti-vax attitudes and COVID-19 vaccine hesitancy prior to widespread vaccine availability
por: Roberts, Hannah A., et al.
Publicado: (2022)

MUC1 Specific Immune Responses Enhanced by Coadministration of Liposomal DDA/MPLA and Lipoglycopeptide
por: Du, Jing-Jing, et al.
Publicado: (2022)

VAX Software Overview
por: DELPHI Collaboration
Publicado: (1982)

Central VAX upgrade
Publicado: (1987)

VAX support installation
por: Luque, Maria
Publicado: (2021)

Novel and safe single-dose treatment of cutaneous leishmaniasis with implantable amphotericin B-loaded microparticles
por: Sousa-Batista, Ariane J., et al.
Publicado: (2019)

Membrane TLR9 Positive Neutrophil Mediated MPLA Protects Against Fatal Bacterial Sepsis
por: Yang, Zhaogang, et al.
Publicado: (2019)

An old drug and different ways to treat cutaneous leishmaniasis: Intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil
por: Oliveira-Ribeiro, Carla, et al.
Publicado: (2021)

Recombinant full-length Bacillus Anthracis protective antigen and its 63 kDa form elicits protective response in formulation with addavax
por: Sharma, Shikhar, et al.
Publicado: (2023)

Intranasal vaccination with extracellular serine proteases of Leishmania amazonensis confers protective immunity to BALB/c mice against infection
por: de Matos Guedes, Herbert Leonel, et al.
Publicado: (2014)

Model of the VAX-11/780
Publicado: (1977)

New VAX computer arrives
Publicado: (1985)

VAX architecture reference manual /
Publicado: (1987)

Cannot write session to /tmp/vufind_sessions/sess_4au7tl73vi5r0a73n1d2v518o0