Determinants for α4β2 vs. α3β4 Subtype Selectivity of Pyrrolidine-Based nAChRs Ligands: A Computational Perspective with Focus on Recent cryo-EM Receptor Structures

The selectivity of α4β2 nAChR agonists over the α3β4 nicotinic receptor subtype, predominant in ganglia, primarily conditions their therapeutic range and it is still a complex and challenging issue for medicinal chemists and pharmacologists. Here, we investigate the determinants for such subtype sel...

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Detalles Bibliográficos
Autores principales: Bavo, Francesco, Pallavicini, Marco, Appiani, Rebecca, Bolchi, Cristiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231201/
https://www.ncbi.nlm.nih.gov/pubmed/34204637
http://dx.doi.org/10.3390/molecules26123603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231201/
https://www.ncbi.nlm.nih.gov/pubmed/34204637
http://dx.doi.org/10.3390/molecules26123603

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