CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion

AIM: Despite the enormous efforts to understand Congenital hyperinsulinism (CHI), up to 50% of the patients are genetically unexplained. We aimed to functionally characterize a novel candidate gene in CHI. PATIENT: A 4-month-old boy presented severe hyperinsulinemic hypoglycemia. A routine CHI genet...

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Detalles Bibliográficos
Autores principales: Alhaidan, Yazeid, Christesen, Henrik Thybo, Lundberg, Elena, Balwi, Mohammed A. Al, Brusgaard, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231291/
https://www.ncbi.nlm.nih.gov/pubmed/34177802
http://dx.doi.org/10.3389/fendo.2021.657873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231291/
https://www.ncbi.nlm.nih.gov/pubmed/34177802
http://dx.doi.org/10.3389/fendo.2021.657873

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