Preclinical Development of FA5, a Novel AMP-Activated Protein Kinase (AMPK) Activator as an Innovative Drug for the Management of Bowel Inflammation

Acadesine (ACA), a pharmacological activator of AMP-activated protein kinase (AMPK), showed a promising beneficial effect in a mouse model of colitis, indicating this drug as an alternative tool to manage IBDs. However, ACA displays some pharmacodynamic limitations precluding its therapeutical appli...

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Detalles Bibliográficos
Autores principales: Antonioli, Luca, Pellegrini, Carolina, Fornai, Matteo, Benvenuti, Laura, D’Antongiovanni, Vanessa, Colucci, Rocchina, Bertani, Lorenzo, Di Salvo, Clelia, Semeghini, Giorgia, La Motta, Concettina, Giusti, Laura, Zallocco, Lorenzo, Ronci, Maurizio, Quattrini, Luca, Angelucci, Francesco, Coviello, Vito, Oh, Won-Keun, Ha, Quy Thi Kim, Németh, Zoltan H., Haskó, Gyorgy, Blandizzi, Corrado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231528/
https://www.ncbi.nlm.nih.gov/pubmed/34199160
http://dx.doi.org/10.3390/ijms22126325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231528/
https://www.ncbi.nlm.nih.gov/pubmed/34199160
http://dx.doi.org/10.3390/ijms22126325

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