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Preclinical Development of FA5, a Novel AMP-Activated Protein Kinase (AMPK) Activator as an Innovative Drug for the Management of Bowel Inflammation
Acadesine (ACA), a pharmacological activator of AMP-activated protein kinase (AMPK), showed a promising beneficial effect in a mouse model of colitis, indicating this drug as an alternative tool to manage IBDs. However, ACA displays some pharmacodynamic limitations precluding its therapeutical appli...
Autores principales: | Antonioli, Luca, Pellegrini, Carolina, Fornai, Matteo, Benvenuti, Laura, D’Antongiovanni, Vanessa, Colucci, Rocchina, Bertani, Lorenzo, Di Salvo, Clelia, Semeghini, Giorgia, La Motta, Concettina, Giusti, Laura, Zallocco, Lorenzo, Ronci, Maurizio, Quattrini, Luca, Angelucci, Francesco, Coviello, Vito, Oh, Won-Keun, Ha, Quy Thi Kim, Németh, Zoltan H., Haskó, Gyorgy, Blandizzi, Corrado |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231528/ https://www.ncbi.nlm.nih.gov/pubmed/34199160 http://dx.doi.org/10.3390/ijms22126325 |
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