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Multiple Roles of SARS-CoV-2 N Protein Facilitated by Proteoform-Specific Interactions with RNA, Host Proteins, and Convalescent Antibodies
[Image: see text] The SARS-CoV-2 nucleocapsid (N) protein is a highly immunogenic viral protein that plays essential roles in replication and virion assembly. Here, using native mass spectrometry, we show that dimers are the functional unit of ribonucleoprotein assembly and that N protein binds RNA...
Autores principales: | Lutomski, Corinne A., El-Baba, Tarick J., Bolla, Jani R., Robinson, Carol V. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231660/ https://www.ncbi.nlm.nih.gov/pubmed/34462738 http://dx.doi.org/10.1021/jacsau.1c00139 |
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