The Role of Non-Enzymatic Degradation of Meropenem—Insights from the Bottle to the Body

Several studies have addressed the poor stability of meropenem in aqueous solutions, though not considering the main degradation product, the open-ring metabolite (ORM) form. In the present work, we elucidate the metabolic fate of meropenem and ORM from continuous infusion to the human bloodstream....

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Detalles Bibliográficos
Autores principales: Liebchen, Uwe, Rakete, Sophie, Vogeser, Michael, Arend, Florian M., Kinast, Christina, Scharf, Christina, Zoller, Michael, Schönermarck, Ulf, Paal, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231794/
https://www.ncbi.nlm.nih.gov/pubmed/34198482
http://dx.doi.org/10.3390/antibiotics10060715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231794/
https://www.ncbi.nlm.nih.gov/pubmed/34198482
http://dx.doi.org/10.3390/antibiotics10060715

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