Association between Predicted Effects of TP53 Missense Variants on Protein Conformation and Their Phenotypic Presentation as Li-Fraumeni Syndrome or Hereditary Breast Cancer

Rare germline pathogenic TP53 missense variants often predispose to a wide spectrum of tumors characterized by Li-Fraumeni syndrome (LFS) but a subset of variants is also seen in families with exclusively hereditary breast cancer (HBC) outcomes. We have developed a logistic regression model with the...

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Detalles Bibliográficos
Autores principales: Liu, Yaxuan, Axell, Olga, van Leeuwen, Tom, Konrat, Robert, Kharaziha, Pedram, Larsson, Catharina, Wright, Anthony P. H., Bajalica-Lagercrantz, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231809/
https://www.ncbi.nlm.nih.gov/pubmed/34198491
http://dx.doi.org/10.3390/ijms22126345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231809/
https://www.ncbi.nlm.nih.gov/pubmed/34198491
http://dx.doi.org/10.3390/ijms22126345

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