n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway

Spinocerebellar ataxia type 3 (SCA3), a hereditary and lethal neurodegenerative disease, is attributed to the abnormal accumulation of undegradable polyglutamine (polyQ), which is encoded by mutated ataxin-3 gene (ATXN3). The toxic fragments processed from mutant ATXN3 can induce neuronal death, lea...

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Detalles Bibliográficos
Autores principales: Lee, Jui-Hao, Lin, Si-Yin, Liu, Jen-Wei, Lin, Shinn-Zong, Harn, Horng-Jyh, Chiou, Tzyy-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231882/
https://www.ncbi.nlm.nih.gov/pubmed/34199295
http://dx.doi.org/10.3390/ijms22126339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231882/
https://www.ncbi.nlm.nih.gov/pubmed/34199295
http://dx.doi.org/10.3390/ijms22126339

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