Glyoxalase-1-Dependent Methylglyoxal Depletion Sustains PD-L1 Expression in Metastatic Prostate Cancer Cells: A Novel Mechanism in Cancer Immunosurveillance Escape and a Potential Novel Target to Overcome PD-L1 Blockade Resistance

SIMPLE SUMMARY: Metastatic prostate cancer (mPCa) is a well-known lethal condition. One of the mechanisms through which PCa cells become so aggressive is the avoidance of immune surveillance that further fosters cell growth, invasion, and migration. PD-L1/PD-1 axis plays a crucial role in inhibiting...

Descripción completa

Detalles Bibliográficos
Autores principales: Antognelli, Cinzia, Mandarano, Martina, Prosperi, Enrico, Sidoni, Angelo, Talesa, Vincenzo Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232032/
https://www.ncbi.nlm.nih.gov/pubmed/34199263
http://dx.doi.org/10.3390/cancers13122965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232032/
https://www.ncbi.nlm.nih.gov/pubmed/34199263
http://dx.doi.org/10.3390/cancers13122965

Ejemplares similares