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Glyoxalase-1-Dependent Methylglyoxal Depletion Sustains PD-L1 Expression in Metastatic Prostate Cancer Cells: A Novel Mechanism in Cancer Immunosurveillance Escape and a Potential Novel Target to Overcome PD-L1 Blockade Resistance

SIMPLE SUMMARY: Metastatic prostate cancer (mPCa) is a well-known lethal condition. One of the mechanisms through which PCa cells become so aggressive is the avoidance of immune surveillance that further fosters cell growth, invasion, and migration. PD-L1/PD-1 axis plays a crucial role in inhibiting...

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Detalles Bibliográficos
Autores principales:	Antognelli, Cinzia, Mandarano, Martina, Prosperi, Enrico, Sidoni, Angelo, Talesa, Vincenzo Nicola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232032/ https://www.ncbi.nlm.nih.gov/pubmed/34199263 http://dx.doi.org/10.3390/cancers13122965

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