Pimozide and Imipramine Blue Exploit Mitochondrial Vulnerabilities and Reactive Oxygen Species to Cooperatively Target High Risk Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a heterogeneous disease with a high relapse rate. Cytokine receptor targeted therapies are therapeutically attractive but are subject to resistance-conferring mutations. Likewise, targeting downstream signaling pathways has been difficult. Recent success in the develo...

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Detalles Bibliográficos
Autores principales: Wang, Zhengqi, Mi, Tian, Bradley, Heath L., Metts, Jonathan, Sabnis, Himalee, Zhu, Wandi, Arbiser, Jack, Bunting, Kevin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232307/
https://www.ncbi.nlm.nih.gov/pubmed/34203664
http://dx.doi.org/10.3390/antiox10060956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232307/
https://www.ncbi.nlm.nih.gov/pubmed/34203664
http://dx.doi.org/10.3390/antiox10060956

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