Cargando…

Pimozide and Imipramine Blue Exploit Mitochondrial Vulnerabilities and Reactive Oxygen Species to Cooperatively Target High Risk Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a heterogeneous disease with a high relapse rate. Cytokine receptor targeted therapies are therapeutically attractive but are subject to resistance-conferring mutations. Likewise, targeting downstream signaling pathways has been difficult. Recent success in the develo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Zhengqi, Mi, Tian, Bradley, Heath L., Metts, Jonathan, Sabnis, Himalee, Zhu, Wandi, Arbiser, Jack, Bunting, Kevin D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232307/ https://www.ncbi.nlm.nih.gov/pubmed/34203664 http://dx.doi.org/10.3390/antiox10060956

Ejemplares similares

Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells
por: Metts, Jonathan, et al.
Publicado: (2017)

Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia
por: Laidlaw, Kamilla M.E., et al.
Publicado: (2016)

Capillary nano-immunoassay for Akt 1/2/3 and 4EBP1 phosphorylation in acute myeloid leukemia
por: Sabnis, Himalee, et al.
Publicado: (2014)

Liposome-Imipramine Blue Inhibits Sonic Hedgehog Medulloblastoma In Vivo
por: MacDonald, Tobey J., et al.
Publicado: (2021)

Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature
por: Eason, Ashley C., et al.
Publicado: (2019)

Targeting MYC Dependence by Metabolic Inhibitors in Cancer
por: Sabnis, Himalee S., et al.
Publicado: (2017)

Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia
por: Liu, Xiaoling, et al.
Publicado: (2012)

Pimozide: An Old Wine in a New Bottle!
por: Naguy, Ahmed
Publicado: (2017)

IL-4/10 prevents stress vulnerability following imipramine discontinuation
por: Han, Arum, et al.
Publicado: (2015)

Gastrointestinal absorption of pimozide is enhanced by inhibition of P-glycoprotein
por: Morishita, Hiroki, et al.
Publicado: (2020)

The Cooperative Relationship between STAT5 and Reactive Oxygen Species in Leukemia: Mechanism and Therapeutic Potential
por: Mi, Tian, et al.
Publicado: (2018)

Pimozide Inhibits the Human Prostate Cancer Cells Through the Generation of Reactive Oxygen Species
por: Kim, Ukjin, et al.
Publicado: (2020)

CARDIOGENIC SHOCK WITH IMIPRAMINE
por: Chaudhury, S., et al.
Publicado: (1990)

Pimozide Augmentation of Clozapine in Hebephrenic Schizophrenia: A Case Report
por: Mendhekar, D.N., et al.
Publicado: (2003)

Olfactory Reference Syndrome with Suicidal Attempt Treated with Pimozide and Fluvoxamine
por: Jegede, Oluwole, et al.
Publicado: (2018)

Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia
por: Stuani, Lucille, et al.
Publicado: (2019)

Targeting the Vulnerabilities of Oncogene Activation
por: Huang, Christina, et al.
Publicado: (2023)

The anti-psychotic drug pimozide is a novel chemotherapeutic for breast cancer
por: Dakir, EL-Habib, et al.
Publicado: (2018)

TREATMENT BY IMIPRAMINE OF DEAFNESS AND DEPRESSION
por: Srivastava, V.K.
Publicado: (1998)

Imipramine blocks acute silicosis in a mouse model
por: Biswas, Rupa, et al.
Publicado: (2017)

Pimozide Inhibits the AcrAB-TolC Efflux Pump in Escherichia coli
por: Bohnert, Jürgen A, et al.
Publicado: (2013)

The enhanced antitumour response of pimozide combined with the IDO inhibitor L-MT in melanoma
por: Jia, Huijie, et al.
Publicado: (2018)

Inhibition of wnt/β-catenin Signaling in Hepatocellular Carcinoma by an Antipsychotic Drug Pimozide
por: Fako, Valerie, et al.
Publicado: (2016)

Pimozide Suppresses the Growth of Brain Tumors by Targeting STAT3-Mediated Autophagy
por: Ranjan, Alok, et al.
Publicado: (2020)

IMIPRAMINE IN SCHIZOPHRENIA WITH DEPRESSIVE SYMPTOMATOLOGY1
por: Dua, Dinesh, et al.
Publicado: (1990)

Granulomatous drug eruption associated with imipramine
por: Pascucci, Anabella
Publicado: (2018)

Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells
por: Zielke, Svenja, et al.
Publicado: (2018)

The neuroleptic drug pimozide inhibits stem-like cell maintenance and tumorigenicity in hepatocellular carcinoma
por: Chen, Jia-Jie, et al.
Publicado: (2015)

PD-1-siRNA delivered by attenuated Salmonella enhances the antimelanoma effect of pimozide
por: Zhao, Tiesuo, et al.
Publicado: (2019)

STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts
por: Kinzler, Maximilian N., et al.
Publicado: (2020)

Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells
por: Rattigan, Kevin M, et al.
Publicado: (2023)

A COMPARATIVE EVALUATION OF DOTHIEPIN (PROTHIEDEN) AND IMIPRAMINE
por: Chaturvedi, M. K., et al.
Publicado: (1980)

Accelerated antidepressant response to lithium augmentation of imipramine
por: Saini, Rajiv, et al.
Publicado: (2016)

The next psychoactive drugs: From imipramine to ketamine
por: Carrillo, Pablo, et al.
Publicado: (2020)

Antipsychotic agent pimozide promotes reversible proliferative suppression by inducing cellular quiescence in liver cancer
por: Chen, Jia-Jie, et al.
Publicado: (2019)

Pimozide Increases a Delayed Rectifier K(+) Conductance in Chicken Embryo Vestibular Hair Cells
por: Giunta, Roberta, et al.
Publicado: (2023)

Simultaneous Spectrophotometric Estimation of Imipramine Hydrochloride and Chlordiazepoxide in Tablets
por: Patel, Sejal, et al.
Publicado: (2009)

EFFECT OF IMIPRAMINE AND ECT ON PLATELET MAO ACTIVITY IN DEPRESSIVES
por: Trivedi, J.K., et al.
Publicado: (1989)

A COMPARATIVE STUDY OF DOTHIEPIN (PROTHIADEN) AND IMIPRAMINE IN DEPRESSION
por: Vyas, J.N., et al.
Publicado: (1989)

MULTICENTRIC EFFICACY STUDY OF CENTPROPAZINE AND IMIPRAMINE IN DEPRESSED PATIENTS
por: Srivastava, J.S., et al.
Publicado: (1999)

Cannot write session to /tmp/vufind_sessions/sess_05gursl4mf7rdt6r5c5sdhdd69