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Monomeric bile acids modulate the ATPase activity of detergent-solubilized ABCB4/MDR3

ABCB4, also called multidrug-resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Due to the harsh detergent effect of bi...

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Detalles Bibliográficos
Autores principales: Kroll, Tim, Smits, Sander H.J., Schmitt, Lutz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233136/
https://www.ncbi.nlm.nih.gov/pubmed/34022183
http://dx.doi.org/10.1016/j.jlr.2021.100087