Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent manner

Cellular pyruvate is an essential metabolite at the crossroads of glycolysis and oxidative phosphorylation, capable of supporting fermentative glycolysis by reduction to lactate mediated by lactate dehydrogenase (LDH) among other functions. Several inherited diseases of mitochondrial metabolism impa...

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Detalles Bibliográficos
Autores principales: Rao, Yi, Gammon, Seth T., Sutton, Margie N., Zacharias, Niki M., Bhattacharya, Pratip, Piwnica-Worms, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233206/
https://www.ncbi.nlm.nih.gov/pubmed/34022218
http://dx.doi.org/10.1016/j.jbc.2021.100775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233206/
https://www.ncbi.nlm.nih.gov/pubmed/34022218
http://dx.doi.org/10.1016/j.jbc.2021.100775

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