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Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent manner
Cellular pyruvate is an essential metabolite at the crossroads of glycolysis and oxidative phosphorylation, capable of supporting fermentative glycolysis by reduction to lactate mediated by lactate dehydrogenase (LDH) among other functions. Several inherited diseases of mitochondrial metabolism impa...
Autores principales: | Rao, Yi, Gammon, Seth T., Sutton, Margie N., Zacharias, Niki M., Bhattacharya, Pratip, Piwnica-Worms, David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233206/ https://www.ncbi.nlm.nih.gov/pubmed/34022218 http://dx.doi.org/10.1016/j.jbc.2021.100775 |
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