Potent efficacy of chlorpromazine in acute myeloid leukemia harboring KIT-D816V mutation

Acute myeloid leukemia (AML) is a heterogeneous disease often associated with poor prognosis. We previously showed that the localization of KIT-D816V at endolysosomes is critical to activate aberrant Akt signaling and Chlorpromazine (CPZ) perturbs the intracellular localization, leading to cell deat...

Descripción completa

Detalles Bibliográficos
Autores principales: Rai, Shinya, Tanaka, Hirokazu, Espinoza, J. Luis, Kumode, Takahiro, Matsumura, Itaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233227/
https://www.ncbi.nlm.nih.gov/pubmed/34194969
http://dx.doi.org/10.1016/j.lrr.2021.100256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233227/
https://www.ncbi.nlm.nih.gov/pubmed/34194969
http://dx.doi.org/10.1016/j.lrr.2021.100256

Ejemplares similares