Cargando…
The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release
Membrane-tethered signalling proteins such as TNFα and many EGF receptor ligands undergo shedding by the metalloproteinase ADAM17 to get released. The pseudoproteases iRhom1 and iRhom2 are important for the transport, maturation and activity of ADAM17. Yet, the structural and functional requirements...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233286/ https://www.ncbi.nlm.nih.gov/pubmed/33950315 http://dx.doi.org/10.1007/s00018-021-03845-3 |