Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome

The R47H variant of the microglial membrane receptor TREM2 is linked to increased risk of late onset Alzheimer’s disease. Human induced pluripotent stem cell derived microglia (iPS-Mg) from patient iPSC lines expressing the AD-linked R47H(het) TREM2 variant, common variant (Cv) or an R47H(hom) CRISP...

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Detalles Bibliográficos
Autores principales: Cosker, Katharina, Mallach, Anna, Limaye, Janhavi, Piers, Thomas M., Staddon, James, Neame, Stephen J., Hardy, John, Pocock, Jennifer M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233372/
https://www.ncbi.nlm.nih.gov/pubmed/34172778
http://dx.doi.org/10.1038/s41598-021-91207-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233372/
https://www.ncbi.nlm.nih.gov/pubmed/34172778
http://dx.doi.org/10.1038/s41598-021-91207-1

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