Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro

All medically important unicellular protozoans cannot synthesize purines de novo and they entirely rely on the purine salvage pathway (PSP) for their nucleotide generation. Therefore, purine derivatives have been considered as a promising source of anti-parasitic compounds since they can act as inhi...

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Detalles Bibliográficos
Autores principales: Doleželová, Eva, Klejch, Tomáš, Špaček, Petr, Slapničková, Martina, Guddat, Luke, Hocková, Dana, Zíková, Alena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233378/
https://www.ncbi.nlm.nih.gov/pubmed/34172767
http://dx.doi.org/10.1038/s41598-021-91747-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233378/
https://www.ncbi.nlm.nih.gov/pubmed/34172767
http://dx.doi.org/10.1038/s41598-021-91747-6

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