MCT4 is induced by metastasis-enhancing pathogenic mitochondrial NADH dehydrogenase gene mutations and can be a therapeutic target

Pathogenic mitochondrial NADH dehydrogenase (ND) gene mutations enhance the invasion and metastasis of various cancer cells, and they are associated with metastasis in human non-small cell lung cancer (NSCLC). Moreover, monocarboxylate transporter 4 (MCT4) is overexpressed in solid cancers and plays...

Descripción completa

Detalles Bibliográficos
Autores principales: Takenaga, Keizo, Koshikawa, Nobuko, Akimoto, Miho, Tatsumi, Yasutoshi, Lin, Jason, Itami, Makiko, Nagase, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233425/
https://www.ncbi.nlm.nih.gov/pubmed/34172808
http://dx.doi.org/10.1038/s41598-021-92772-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233425/
https://www.ncbi.nlm.nih.gov/pubmed/34172808
http://dx.doi.org/10.1038/s41598-021-92772-1

Ejemplares similares