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In-depth correlation analysis demonstrates that 4-hydroxyproline at the Yaa position of Gly-Xaa-Yaa repeats dominantly stabilizes collagen triple helix

There is a general consensus that collagen stability is largely maintained by Pro and its major hydroxylated form, 4-hydroxyproline (4Hyp). However, positional difference in their stabilizing effect at the Xaa or Yaa position of collagenous Gly-Xaa-Yaa sequences has remained inconclusive. Here, we p...

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Detalles Bibliográficos
Autores principales: Taga, Yuki, Tanaka, Keisuke, Hattori, Shunji, Mizuno, Kazunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233474/
https://www.ncbi.nlm.nih.gov/pubmed/34195597
http://dx.doi.org/10.1016/j.mbplus.2021.100067