A new mouse mutant with cleavage-resistant versican and isoform-specific versican mutants demonstrate that proteolysis at the Glu(441)-Ala(442) peptide bond in the V1 isoform is essential for interdigital web regression

Two inherent challenges in the mechanistic interpretation of protease-deficient phenotypes are defining the specific substrate cleavages whose reduction generates the phenotypes and determining whether the phenotypes result from loss of substrate function, substrate accumulation, or loss of a functi...

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Detalles Bibliográficos
Autores principales: Nandadasa, Sumeda, Burin des Roziers, Cyril, Koch, Christopher, Tran-Lundmark, Karin, Dours-Zimmermann, María T., Zimmermann, Dieter R., Valleix, Sophie, Apte, Suneel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233476/
https://www.ncbi.nlm.nih.gov/pubmed/34195596
http://dx.doi.org/10.1016/j.mbplus.2021.100064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233476/
https://www.ncbi.nlm.nih.gov/pubmed/34195596
http://dx.doi.org/10.1016/j.mbplus.2021.100064

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