Meropenem-Vaborbactam as Salvage Therapy for Ceftazidime-Avibactam-, Cefiderocol-Resistant ST-512 Klebsiella pneumoniae–Producing KPC-31, a D179Y Variant of KPC-3

A 68-year-old man had recurrent bacteremia by Klebsiella pneumoniae carbapenemase (KPC)–producing K. pneumoniae resistant to ceftazidime-avibactam and cefiderocol. The sequencing of a target region showed that it harbored a KPC-3 variant enzyme (D179Y; KPC-31), which confers resistance to ceftazidim...

Descripción completa

Detalles Bibliográficos
Autores principales: Tiseo, Giusy, Falcone, Marco, Leonildi, Alessandro, Giordano, Cesira, Barnini, Simona, Arcari, Gabriele, Carattoli, Alessandra, Menichetti, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
ID Teaching Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233566/
https://www.ncbi.nlm.nih.gov/pubmed/34189161
http://dx.doi.org/10.1093/ofid/ofab141
_version_ 1783713881301975040
author Tiseo, Giusy
Falcone, Marco
Leonildi, Alessandro
Giordano, Cesira
Barnini, Simona
Arcari, Gabriele
Carattoli, Alessandra
Menichetti, Francesco
author_facet Tiseo, Giusy
Falcone, Marco
Leonildi, Alessandro
Giordano, Cesira
Barnini, Simona
Arcari, Gabriele
Carattoli, Alessandra
Menichetti, Francesco
author_sort Tiseo, Giusy
collection PubMed
description A 68-year-old man had recurrent bacteremia by Klebsiella pneumoniae carbapenemase (KPC)–producing K. pneumoniae resistant to ceftazidime-avibactam and cefiderocol. The sequencing of a target region showed that it harbored a KPC-3 variant enzyme (D179Y; KPC-31), which confers resistance to ceftazidime-avibactam and restores meropenem susceptibility. The patient was successfully treated with meropenem-vaborbactam.
format Online
Article
Text
id pubmed-8233566
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-82335662021-06-28 Meropenem-Vaborbactam as Salvage Therapy for Ceftazidime-Avibactam-, Cefiderocol-Resistant ST-512 Klebsiella pneumoniae–Producing KPC-31, a D179Y Variant of KPC-3 Tiseo, Giusy Falcone, Marco Leonildi, Alessandro Giordano, Cesira Barnini, Simona Arcari, Gabriele Carattoli, Alessandra Menichetti, Francesco Open Forum Infect Dis ID Teaching Cases A 68-year-old man had recurrent bacteremia by Klebsiella pneumoniae carbapenemase (KPC)–producing K. pneumoniae resistant to ceftazidime-avibactam and cefiderocol. The sequencing of a target region showed that it harbored a KPC-3 variant enzyme (D179Y; KPC-31), which confers resistance to ceftazidime-avibactam and restores meropenem susceptibility. The patient was successfully treated with meropenem-vaborbactam. Oxford University Press 2021-03-20 /pmc/articles/PMC8233566/ /pubmed/34189161 http://dx.doi.org/10.1093/ofid/ofab141 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle ID Teaching Cases
Tiseo, Giusy
Falcone, Marco
Leonildi, Alessandro
Giordano, Cesira
Barnini, Simona
Arcari, Gabriele
Carattoli, Alessandra
Menichetti, Francesco
Meropenem-Vaborbactam as Salvage Therapy for Ceftazidime-Avibactam-, Cefiderocol-Resistant ST-512 Klebsiella pneumoniae–Producing KPC-31, a D179Y Variant of KPC-3
title Meropenem-Vaborbactam as Salvage Therapy for Ceftazidime-Avibactam-, Cefiderocol-Resistant ST-512 Klebsiella pneumoniae–Producing KPC-31, a D179Y Variant of KPC-3
title_full Meropenem-Vaborbactam as Salvage Therapy for Ceftazidime-Avibactam-, Cefiderocol-Resistant ST-512 Klebsiella pneumoniae–Producing KPC-31, a D179Y Variant of KPC-3
title_fullStr Meropenem-Vaborbactam as Salvage Therapy for Ceftazidime-Avibactam-, Cefiderocol-Resistant ST-512 Klebsiella pneumoniae–Producing KPC-31, a D179Y Variant of KPC-3
title_full_unstemmed Meropenem-Vaborbactam as Salvage Therapy for Ceftazidime-Avibactam-, Cefiderocol-Resistant ST-512 Klebsiella pneumoniae–Producing KPC-31, a D179Y Variant of KPC-3
title_short Meropenem-Vaborbactam as Salvage Therapy for Ceftazidime-Avibactam-, Cefiderocol-Resistant ST-512 Klebsiella pneumoniae–Producing KPC-31, a D179Y Variant of KPC-3
title_sort meropenem-vaborbactam as salvage therapy for ceftazidime-avibactam-, cefiderocol-resistant st-512 klebsiella pneumoniae–producing kpc-31, a d179y variant of kpc-3
topic ID Teaching Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233566/
https://www.ncbi.nlm.nih.gov/pubmed/34189161
http://dx.doi.org/10.1093/ofid/ofab141
work_keys_str_mv AT tiseogiusy meropenemvaborbactamassalvagetherapyforceftazidimeavibactamcefiderocolresistantst512klebsiellapneumoniaeproducingkpc31ad179yvariantofkpc3
AT falconemarco meropenemvaborbactamassalvagetherapyforceftazidimeavibactamcefiderocolresistantst512klebsiellapneumoniaeproducingkpc31ad179yvariantofkpc3
AT leonildialessandro meropenemvaborbactamassalvagetherapyforceftazidimeavibactamcefiderocolresistantst512klebsiellapneumoniaeproducingkpc31ad179yvariantofkpc3
AT giordanocesira meropenemvaborbactamassalvagetherapyforceftazidimeavibactamcefiderocolresistantst512klebsiellapneumoniaeproducingkpc31ad179yvariantofkpc3
AT barninisimona meropenemvaborbactamassalvagetherapyforceftazidimeavibactamcefiderocolresistantst512klebsiellapneumoniaeproducingkpc31ad179yvariantofkpc3
AT arcarigabriele meropenemvaborbactamassalvagetherapyforceftazidimeavibactamcefiderocolresistantst512klebsiellapneumoniaeproducingkpc31ad179yvariantofkpc3
AT carattolialessandra meropenemvaborbactamassalvagetherapyforceftazidimeavibactamcefiderocolresistantst512klebsiellapneumoniaeproducingkpc31ad179yvariantofkpc3
AT menichettifrancesco meropenemvaborbactamassalvagetherapyforceftazidimeavibactamcefiderocolresistantst512klebsiellapneumoniaeproducingkpc31ad179yvariantofkpc3

Ejemplares similares