Astrocytic apoE4 and tau: Deadly combination for neurons

New data from Wang and colleagues(1) suggest that astrocyte-derived apoE4 drives tau-mediated neurodegeneration. This research highlights how a genetic risk factor for Alzheimer’s disease is a major determinant of neurodegeneration in tau-expressing neurons by regulating non-cell-autonomous pathways...

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Detalles Bibliográficos
Autores principales: Chakrabarty, Paramita, Borchelt, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233647/
https://www.ncbi.nlm.nih.gov/pubmed/34195681
http://dx.doi.org/10.1016/j.xcrm.2021.100316
Descripción
Sumario:New data from Wang and colleagues(1) suggest that astrocyte-derived apoE4 drives tau-mediated neurodegeneration. This research highlights how a genetic risk factor for Alzheimer’s disease is a major determinant of neurodegeneration in tau-expressing neurons by regulating non-cell-autonomous pathways.

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