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Astrocytic apoE4 and tau: Deadly combination for neurons
New data from Wang and colleagues(1) suggest that astrocyte-derived apoE4 drives tau-mediated neurodegeneration. This research highlights how a genetic risk factor for Alzheimer’s disease is a major determinant of neurodegeneration in tau-expressing neurons by regulating non-cell-autonomous pathways...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233647/ https://www.ncbi.nlm.nih.gov/pubmed/34195681 http://dx.doi.org/10.1016/j.xcrm.2021.100316 |
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author | Chakrabarty, Paramita Borchelt, David R. |
author_facet | Chakrabarty, Paramita Borchelt, David R. |
author_sort | Chakrabarty, Paramita |
collection | PubMed |
description | New data from Wang and colleagues(1) suggest that astrocyte-derived apoE4 drives tau-mediated neurodegeneration. This research highlights how a genetic risk factor for Alzheimer’s disease is a major determinant of neurodegeneration in tau-expressing neurons by regulating non-cell-autonomous pathways. |
format | Online Article Text |
id | pubmed-8233647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-82336472021-06-29 Astrocytic apoE4 and tau: Deadly combination for neurons Chakrabarty, Paramita Borchelt, David R. Cell Rep Med Preview New data from Wang and colleagues(1) suggest that astrocyte-derived apoE4 drives tau-mediated neurodegeneration. This research highlights how a genetic risk factor for Alzheimer’s disease is a major determinant of neurodegeneration in tau-expressing neurons by regulating non-cell-autonomous pathways. Elsevier 2021-06-15 /pmc/articles/PMC8233647/ /pubmed/34195681 http://dx.doi.org/10.1016/j.xcrm.2021.100316 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Preview Chakrabarty, Paramita Borchelt, David R. Astrocytic apoE4 and tau: Deadly combination for neurons |
title | Astrocytic apoE4 and tau: Deadly combination for neurons |
title_full | Astrocytic apoE4 and tau: Deadly combination for neurons |
title_fullStr | Astrocytic apoE4 and tau: Deadly combination for neurons |
title_full_unstemmed | Astrocytic apoE4 and tau: Deadly combination for neurons |
title_short | Astrocytic apoE4 and tau: Deadly combination for neurons |
title_sort | astrocytic apoe4 and tau: deadly combination for neurons |
topic | Preview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233647/ https://www.ncbi.nlm.nih.gov/pubmed/34195681 http://dx.doi.org/10.1016/j.xcrm.2021.100316 |
work_keys_str_mv | AT chakrabartyparamita astrocyticapoe4andtaudeadlycombinationforneurons AT borcheltdavidr astrocyticapoe4andtaudeadlycombinationforneurons |