Astrocytic apoE4 and tau: Deadly combination for neurons

New data from Wang and colleagues(1) suggest that astrocyte-derived apoE4 drives tau-mediated neurodegeneration. This research highlights how a genetic risk factor for Alzheimer’s disease is a major determinant of neurodegeneration in tau-expressing neurons by regulating non-cell-autonomous pathways...

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Detalles Bibliográficos
Autores principales: Chakrabarty, Paramita, Borchelt, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233647/
https://www.ncbi.nlm.nih.gov/pubmed/34195681
http://dx.doi.org/10.1016/j.xcrm.2021.100316
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author Chakrabarty, Paramita
Borchelt, David R.
author_facet Chakrabarty, Paramita
Borchelt, David R.
author_sort Chakrabarty, Paramita
collection PubMed
description New data from Wang and colleagues(1) suggest that astrocyte-derived apoE4 drives tau-mediated neurodegeneration. This research highlights how a genetic risk factor for Alzheimer’s disease is a major determinant of neurodegeneration in tau-expressing neurons by regulating non-cell-autonomous pathways.
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spelling pubmed-82336472021-06-29 Astrocytic apoE4 and tau: Deadly combination for neurons Chakrabarty, Paramita Borchelt, David R. Cell Rep Med Preview New data from Wang and colleagues(1) suggest that astrocyte-derived apoE4 drives tau-mediated neurodegeneration. This research highlights how a genetic risk factor for Alzheimer’s disease is a major determinant of neurodegeneration in tau-expressing neurons by regulating non-cell-autonomous pathways. Elsevier 2021-06-15 /pmc/articles/PMC8233647/ /pubmed/34195681 http://dx.doi.org/10.1016/j.xcrm.2021.100316 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preview
Chakrabarty, Paramita
Borchelt, David R.
Astrocytic apoE4 and tau: Deadly combination for neurons
title Astrocytic apoE4 and tau: Deadly combination for neurons
title_full Astrocytic apoE4 and tau: Deadly combination for neurons
title_fullStr Astrocytic apoE4 and tau: Deadly combination for neurons
title_full_unstemmed Astrocytic apoE4 and tau: Deadly combination for neurons
title_short Astrocytic apoE4 and tau: Deadly combination for neurons
title_sort astrocytic apoe4 and tau: deadly combination for neurons
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233647/
https://www.ncbi.nlm.nih.gov/pubmed/34195681
http://dx.doi.org/10.1016/j.xcrm.2021.100316
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