Imaging-Based Characterization of a Slco2b1((-/-)) Mouse Model Using [(11)C]Erlotinib and [(99m)Tc]Mebrofenin as Probe Substrates

Organic anion-transporting polypeptide 2B1 (OATP2B1) is co-localized with OATP1B1 and OATP1B3 in the basolateral hepatocyte membrane, where it is thought to contribute to the hepatic uptake of drugs. We characterized a novel Slco2b1((-/-)) mouse model using positron emission tomography (PET) imaging...

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Detalles Bibliográficos
Autores principales: Marie, Solène, Hernández-Lozano, Irene, Breuil, Louise, Truillet, Charles, Hu, Shuiying, Sparreboom, Alex, Tournier, Nicolas, Langer, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233734/
https://www.ncbi.nlm.nih.gov/pubmed/34205780
http://dx.doi.org/10.3390/pharmaceutics13060918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233734/
https://www.ncbi.nlm.nih.gov/pubmed/34205780
http://dx.doi.org/10.3390/pharmaceutics13060918

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