Discovery of Selective Inhibitor Leads by Targeting an Allosteric Site in Insulin-Regulated Aminopeptidase

Insulin-Regulated aminopeptidase (IRAP) is a zinc-dependent aminopeptidase with several important biological functions and is an emerging pharmaceutical target for cognitive enhancement and immune system regulation. Aiming to discover lead-like IRAP inhibitors with enhanced selectivity versus homolo...

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Detalles Bibliográficos
Autores principales: Temponeras, Ioannis, Chiniadis, Lykourgos, Papakyriakou, Athanasios, Stratikos, Efstratios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233869/
https://www.ncbi.nlm.nih.gov/pubmed/34207179
http://dx.doi.org/10.3390/ph14060584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233869/
https://www.ncbi.nlm.nih.gov/pubmed/34207179
http://dx.doi.org/10.3390/ph14060584

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