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Discovery of Selective Inhibitor Leads by Targeting an Allosteric Site in Insulin-Regulated Aminopeptidase

Insulin-Regulated aminopeptidase (IRAP) is a zinc-dependent aminopeptidase with several important biological functions and is an emerging pharmaceutical target for cognitive enhancement and immune system regulation. Aiming to discover lead-like IRAP inhibitors with enhanced selectivity versus homolo...

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Detalles Bibliográficos
Autores principales:	Temponeras, Ioannis, Chiniadis, Lykourgos, Papakyriakou, Athanasios, Stratikos, Efstratios
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233869/ https://www.ncbi.nlm.nih.gov/pubmed/34207179 http://dx.doi.org/10.3390/ph14060584

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